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Hošek Jan

doc. RNDr. Jan Hošek, Ph.D.

researcher

Research activities

IN VITRO AND EX VIVO MODELS

MOLECULAR PHARMACOLOGY

EVALUATION OF NOVEL LOW-MOLECULAR-WEIGHT DRUGS

DEVELOPMENT AND ANALYSIS OF GLUCAN-BASED DRUG VEHICLES

Project involvement

CEREBIT (Centre for Recombinant Biotechnologies and Immunotherapeutics)

OP RDE project of the Ministry of Education, Youth and Sports of the Czech Republic – Reg.No. CZ.02.1.01/0.0/0.0/16_025/0007397

FIT (Pharmacology, Immunotherapy, nanoToxicology)

OP RDE project of the Ministry of Education, Youth and Sports of the Czech Republic – Reg.No. CZ.02.1.01/0.0/0.0/15_003/0000495

Education

2019

Habilitation in the field of Genomics and Proteomics, Faculty of Science, Masaryk University Brno

Habilitation thesis: “Regulation of the expression and activity of proteins involved in the inflammatory response by natural flavonoids”

Appointed: 1st May 2019, acquired degree: docent (associate professor)

2006 – 2011

Postgraduate study programme at Department of General and Molecular Genetics, Faculty of Science, Masaryk University Brno

Dissertation thesis: “Study of plant compounds with anti-phlogistic effect on the expression of genes connected with inflammatory reaction”

Final state examination: 20th January 2011, acquired degree: Ph.D.

2008

Advanced state examination at Department of General and Molecular Genetics, Faculty of Science, Masaryk University Brno

Advanced thesis: “Single-nucleotide polymorphismus associated to chronic inflammatory bowel disease”

Final state examination: 10th December 2008, acquired degree: RNDr.

2001–2006

Master study programme Department of Genetic and Molecular Biology, Faculty of Science, Masaryk University Brno

Master thesis: “Preparing of PCR internal standards for detection and differentiation of Mycobacterium avium strains”

Final state examination: 20th June 2006, acquired degree: Mgr.

2001–2004

Bachelor study programme at Department of Genetic and Molecular Biology, Faculty of Science, Masaryk University Brno

Bachelor thesis: “Detection of veterinary important mycobacteria in clinical samples”

Final state examination: 24th June 2004, acquired degree: Bc.

Selected publications

Treml J., Šalamúnová P., Hanuš J., Hošek J. 2021. The effect of curcumin encapsulation into yeast glucan particles on antioxidant enzymes expression in vitro. Food & Function.12: 1954-1957.

Cerulli A., Napolitano A., Hošek J., Masullo M., Pizza C., Piacente S. 2021. Antioxidant and In Vitro Preliminary Anti‐Inflammatory Activity of Castanea sativa (Italian Cultivar “Marrone di Roccadaspide” PGI) Burs, Leaves and Chestnuts Extracts    and their Metabolite Profiles by LC‐ESI/LTQOrbitrap/MS/MS. Antioxidants. 10: 278.

Magar P., Parravicini O., Štěpánková Š., Svrčková K., Garro A.D., Jendrzejewska I., Pauk K., Hošek J., Jampílek J., Enriz, R.D., Imramovský A. 2021. Novel Sulfonamide-Based Carbamates as Selective Inhibitors of BChE. Int. J. Mol. Sci. 22: 9447.