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AZV NV19-04-00270

Assessment of hemodynamic parameters of stable and unstable atherosclerotic plaques in the carotid arteries in in vitro models

Project objectives

The goal of carotid endarterectomy is prevention of ischemic stroke, one of the most common causes of morbidity or mortality in developed countries. The current indication criteria are primarily based on the grade of stenosis caused by the atherosclerotic plaque. Even though it is known that the character of atherosclerotic plaque may be associated with the risk of clinical symptoms, this parameter is not expressed in the recommendations of the American Heart Association (AHA). The development and the character or the plaque are probably influenced by the hemodynamics in the carotid arteries. The goal of our project is to describe the relationship between the hemodynamic parameters and the character of the plaque. The mathematical calculations will be verified with laboratory modelling. The vision of our project is to obtain a tool that would help in early differentiation between risky and less risky plaques and provide the possibility of early intervention before the onset of clinical symptomatology thus making the preventive measures, such as carotid endarterectomy, more effective.

NV19-04-00270

VS – Public tender

14,734 thou. CZK

Participant

The Military University Hospital Prague

The St. Anne’s University Hospital in Brno

University Hospital Ostrava

Charles University

Hospitals and Health Care Usti nad Labem

Project researcher