The Differential scanning calorimeter MicroCal PEAQ-DSC is an automated analytical instrument for characterizing the thermal stability of biomolecules. Characterization involves the determination of the enthalpy, heat capacity, and transit temperature of thermally induced structural changes in the molecule in a solution. The instrument is equipped with a tempered (range 4 °C to 40 °C) sample storage in the form of 96-well disposable plates of 6 positions (96×6 in total, the measuring, and the reference cell (volume of 130 μl) are automated filled. The optimum sample volume is 325 μl over a concentration range of 0.01 mg/ml to 10 mg/ml, depending on the nature of the sample. The measurement is carried out in a temperature range of 2 °C to 130 °C with a maximum heating rate of 240 °C/h and a cooling rate of 60 °C/h.